WHAT IS PREDICT?
PREDICT stands for Pharmacogenomic Resource for Enhanced Decisions in Care & Treatment and is part of Vanderbilt’s Personalized Medicine program.
Personalized Medicine involves tailoring treatments to a patient’s genetic profile. The PREDICT initiative serves to empower patients and physicians with the information necessary to anticipate and prevent adverse drug events or lack of effectiveness based on genetic information specific to each patient tested (drug-gene interactions). The ultimate goal is to select the right drug and the right dose, the first time.
WHO IS ELIGIBLE FOR THE PREDICT TEST?
Any Vanderbilt University Medical Center (VUMC) patient is eligible for the PREDICT test. Reimbursement rates vary based on the patient’s health insurance and medical necessity.
WHAT IS BEING TESTED?
DNA extracted from the patient’s blood will be genotyped for 38 single nucleotide polymorphisms (SNPs) within ten genes associated with drug absorption, distribution, metabolism, and excretion using the QuantStudio Custom Assay PCR System. We currently test for CYP2C19, TPMT, NUDT15, DPYD, VKORC1, CYP2C9, CYP3A5, CYP4F2, SLC01B1, and CYP2D6.
HOW CAN I ORDER THE TEST?
Please use the PREDICT Tip Sheet available on Hubble to guide you through ordering. Once you have logged in, search ‘PREDICT’ within the tip sheets tab and the instructions will appear as a PDF. Additionally, short training videos are available on the Learning Exchange for those who would like a walkthrough on how to order the PREDICT test. Open the link above, or go to the Learning Exchange website and search for ‘PREDICT’.
HOW WILL I RECEIVE THE RESULTS?
The drug-gene interactions that have been reviewed and approved as actionable by the Vanderbilt Pharmacy & Therapeutics (P&T) subcommittees will be made available for point-of-care clinical decision support. These genetic results will be stored within eStar (Vanderbilt’s electronic health record) under the tabs for genomic indicators and lab results. Please visit the Learning Exchange for a short video on how to find your results in eStar. These results are also available to the patient at MyHealth@Vanderbilt.
If a patient has had PREDICT testing and a provider orders a medication wherein a patient has a genetically actionable result on file, a best practice advisory (BPA) message will fire to alert the provider. Depending on the results of the test, dosage adjustments for specific drugs or alternative medications may be recommended for the patient. Providers may also access a patient’s results within the electronic health record prior to prescribing by looking at the lab test results or the genomic indicators sections within eStar.
WHAT IF I HAVE QUESTIONS ABOUT THE RESULTS?
The PREDICT team has a pharmacogenomics clinical pharmacist specialist that is available to providers for consultation. If you are a VUMC provider with specific questions related to the interpretation of the PREDICT test, please consult our specialist through the Pharmacogenomics eConsult orderable found in eSTAR and available within select BPAs.
The Genomics and Therapeutics Clinic (GATC) is available to help healthcare providers who are looking for guidance on pharmacogenomic testing and results. The GATC clinic can review whether the PREDICT test is clinically indicated and help you integrate pharmacogenomic results into your healthcare plan. Referral to the VUMC Genomics and Therapeutics Clinic can be made through eSTAR. Visit their webpage or contact GATC@vumc.org for more information.
For all other questions related to the PREDICT test, please use the ‘Contact Us’ form above to learn more about this offering.